T-CiRA A joint program between Takeda and Center for iPS Cell Research and Application (CiRA)  that will change the future of medicine using iPS cells

Izumo Seigo Global Head of
Regenerative Medicine Unit of Shonan Research center

Shinya Yamanaka Director of Center for
iPS Cell Research and Application (CiRA), Kyoto University

T-CiRA A joint program between Takeda and Center for iPS Cell Research and Application (CiRA)  that will change the future of medicine using iPS cells
T-CiRA A joint program between Takeda and Center for iPS Cell Research and Application (CiRA)  that will change the future of medicine using iPS cells
T-CiRA A joint program between Takeda and Center for iPS Cell Research and Application (CiRA)  that will change the future of medicine using iPS cells

T-CiRA

This visual symbolizes the nature of this joint program.
The four colors, red, blue, green and black - applied in the visual symbolize the four defined factors CiRA used when first inducing iPS cells, as well as interaction among patients, researchers, clinicians and iPS cells. The red is not only one of CiRA's image color but is also Takeda's symbol color.

The center of the emblem is a paper crane, which in Japan, represents hopes and prayers for patients. We hope to deliver innovative medicines to patients as quickly as possible. The tri-colored circle surrounding the crane represents T-CiRA striving toward drug discovery through clinical applications of basic research of iPS through diversified projects, as a one team.

T-CiRA Joint Program

Collaborative research aiming to develop
innovative treatments over a 10-year period

T-CiRA is a joint research program by the Center for iPS Cell Research and Application (CiRA), Kyoto University and Takeda Pharmaceutical Company Limited. Over a 10-year period and under the direction of CiRA, this joint program will conduct research to develop clinical applications of iPS cells. We aim to develop innovative drugs and cell treatments in such areas as heart failure, diabetes mellitus, neuro-psychiatric disorders, cancer and intractable muscle diseases in order to fulfill the needs of patients promptly.

Professor Shinya Yamanaka Director of Center for iPS Cell Research and Application (CiRA), Kyoto University

"This 10-year joint program with Takeda, Japan's largest pharmaceutical company, will become a powerful engine to realize medical applications using iPS cells," said Yamanaka. "We sincerely thank Takeda's commitment to iPS cell research. This partnership will contribute to the development of new therapies to cure not only major diseases but also rare ones."

Christophe Weber Representative Director, President & CEO, Takeda

"I am excited that we will be able to collaborate with CiRA, the world's leading institute dedicated to pioneering iPS cell research," said Christophe Weber, President, and Chief Executive Officer of Takeda. "Through this partnership, our company will provide significant assistance over a long period to CiRA's research into iPS cell technology applications, which is a vital part of Japan Revitalization Strategy. It is our hope to deliver innovative treatments that meet patient needs as soon as possible through this collaboration between Takeda and CiRA."

T-CiRA (Takeda-CiRA) Joint Program Framework

  • Leader: Professor Shinya Yamanaka (Director of CiRA)
  • Goal: Develop clinical application of induced pluripotent stem (iPS) cells
  • Areas: Heart failure, diabetes mellitus, neuro-psychiatric disorders, cancer and intractable muscle diseases, etc.
  • Takeda

    • To provide collaborative funding of 20 billion yen over a 10-year period
    • To provide more than 12 billion yen worth of research support
    • To provide R&D know-how
    • To provide research facilities at Shonan Research Center
    • To provide platform for drug development
    • To provide access to compound libraries
    • To provide researchers
  • CiRA

    • To direct the research program
    • To provide iPS cell technologies
    • To provide drug development targets and assay systems
    • To provide principle investigators, researchers and postdoctoral fellows
  • Shonan Research Center

    A global research center, created by merging the Osaka and Tsukuba Research Centers, helps accelerate innovations in drug development. Here, approximately 1,200 researchers conduct non-clinical research from the early stages of the R&D process such as drug targeting and compound candidate selection to placing drugs on the market.

Cell Therapies
Disease Models
Medicines

The Research

Cutting-edge research towards the clinical
application of iPS cells

Center for iPS Cell Research and Application (CiRA) will possibly bring on breakthrough changes to the future of medicine including the research and development of new drugs, cell therapies and drug safety evaluation processes. T-CiRA will conduct cutting-edge research towards the clinical application of iPS cells in areas such as heart failure, diabetes mellitus, neuro-psychiatric disorders, cancer and intractable muscle diseases at Takeda's Shonan Research Center.

Research to be conducted by T-CiRA

Main Areas of Research

  • Research towards the clinical application of iPS cells for heart failure, diabetes mellitus, neuro-psychiatric disorders, cancer and intractable muscle diseases, etc.
  • Research to develop medicines and cell therapies using iPS cells.

Project Details

  • Akitsu Hotta (PI)
    Naoto Inukai (Co PI from Takeda)
    Eriya Kenjyo (Sub PI from Takeda)
    Hiroyuki Hozumi (Sub PI from Takeda)
    Therapeutic genome editing for congenital muscular dystrophy
    Dr. Hotta’s team aims to correct the causal genetic mutations involved in severe muscular dystrophy using state-of-the-art genome editing and delivery technologies. The team aims to develop proprietary technology that will enable them to create new gene therapies while, at the same time, confirming repair efficiency and safety using patient-derived iPS cells.
  • Haruhisa Inoue (PI)
    Takeshi Niki (Sub PI from CiRA)
    Takeshi Hioki (Sub PI from Takeda)
    Makoto Furusawa (Sub PI from Takeda)
    ALS drug discovery and development using patient-derived iPSCs
    Dr. Inoue’s team conducts research into amyotrophic lateral sclerosis (ALS), a neurodegenerative disease for which there is no effective cure. They aim to develop new therapeutic drugs using patient-derived iPSCs and Takeda's compound libraries.
  • Hidetoshi Sakurai (PI)
    Yuko Kokubu (Sub PI from CiRA)
    Tomoya Uchimura (Sub PI from CiRA)
    Ryuichi Tozawa (Co PI from Takeda)
    Tomoko Nagino (Sub PI from Takeda)
    Masahiro Oka (Sub PI from Takeda)
    Drug discovery for intractable muscular disease using patient-derived iPSCs
    Dr. Sakurai's team will create novel therapeutic drugs for intractable muscular diseases such as muscular dystrophy and investigate muscular disease models. To achieve this goal, they will utilize patient-derived iPSCs as a tool for disease modeling and drug screening.
  • Makoto Ikeya (PI)
    Daisuke Kamiya (Sub PI from CiRA)
    Yayoi Toyooka (Sub PI from CiRA)
    Asano Asami (Co PI from Takeda)
    Kazumi Take (Sub PI from Takeda)
    A new research platform with human iPSC-derived neural crest cells and its applications for drug discovery and regenerative medicine
    Neural crest cells differentiate into diverse cell type lineages such as bones and peripheral neurons, suggesting their great potential for clinical applications. Dr. Ikeya’s team aims to create methods to maintain cultures of human iPSC-derived neural crest stem cells and to induce them to differentiate into various types of cells. Moreover, they hope to construct an disease model in combination with related technologies and apply it to drug development and regenerative medicine.
  • Shin Kaneko (PI)
    Yuta Mishima (Sub PI from CiRA)
    Shoichi Iriguchi (Sub PI from CiRA)
    Akira Hayashi (Co PI from Takeda)
    Yoshiaki Kassai (Co PI from Takeda)
    Development of a novel immunotherapy using iPSC-derived cancer antigen-specific T-cells
    Dr. Kaneko's team is trying to develop a novel cancer immunotherapy using iPSC-derived immune cells. We aspire to realize "off-the-shelf" allogeneic products for cancer patients by combining CiRA's human iPS cell stock for regenerative medicine with Takeda's experience in drug production.
  • Tadashi Suzuki (PI)
    Hiroto Hirayama (Sub PI from CiRA)
    Ryuichi Tozawa (Co-PI from Takeda)
    Takayuki Kamei (Sub PI from Takeda)
    Development of therapeutic agents for rare hereditary diseases using iPS cells
    Dr. Suzuki's team is focusing on a deficiency in the NGLY1 gene that encodes for the de-N-glycosylating enzyme N-glycanase. They will develop innovative therapeutics for NGLY1 deficiency, a rare inherited disease that presently does not have any therapeutic options, through a combination of basic research findings, iPSC technology and a drug discovery platform.
  • Takanori Takebe (PI)
    Masaru Koido (Sub-PI from Yokohama City University)
    Tadahiro Shinozawa (Co PI from Takeda)
    Yasunori Nio (Sub PI from Takeda)
    Miniature liver technology as a platform for research towards pharmaceutical applications
    Based on human iPSC-derived miniature liver technology developed at Yokohama City University, Dr. Takebe’s team is developing a innovative system that can reproduce the complex phenomena found within patients’ bodies. This research will create a novel drug discovery system for intractable diseases and a novel predictive platform for expression analysis of rare adverse events unforeseen in traditional drug discovery research.
  • Taro Toyoda (PI)
    Hirokazu Matsumoto (Co PI from Takeda)
    Yutaka Tanoue (Sub PI from Takeda)
    Ryo Ito (Sub PI from Takeda)
    iPS cell technology-based cell therapy for type 1 diabetes
    Dr. Toyoda's team is conducting research into cell therapy against type 1 diabetes mellitus involving transplants of iPSC-derived pancreatic cells. Their current research aim is to develop new treatments based on islet transplantation, but without the current limitations of such transplantation.
  • Yoshinori Yoshida (PI)
    Kenji Miki (Sub PI from CiRA)
    Tomoyuki Nishimoto (Co PI from Takeda)
    Norihisa Tamura (Sub PI from Takeda)
    Development of an iPSC-based drug discovery platform and application to novel therapy for heart failure
    Dr. Yoshida's team aims to create iPSC-derived cardiomyocytes suitable for regenerative therapy and drug discovery research using new technologies such as microRNA-switch technology developed at CiRA. With these cardiomyocytes, they aim to develop cell therapies against heart failure alongside next-generation drug discovery platform and new therapeutic drugs.

Putting the Promise of iPS Cells into Clinical Practice

Induced pluripotent stem (iPS) cells can differentiate into a variety of cell types
  • β-cell (Pancreas)
  • T-cell (Immune system)
  • Cardiomyocyte (Heart)
  • Neuron (Nervous system)
  • Skeletal muscle cell(skeletal muscle)
  • Hepatocyte (Liver)
  • Neural crest cell

Career Opportunities

Come and change the future of medicine with us

T-CiRA recruits researchers that will change the future of medicine using iPS cells with us.

Takeda and CiRA will each recruit 50 researchers (100 researchers in total) from around the world to conduct research at Shonan Research Center.

We are seeking proposals of new research challenges (projects), and principle investigators (Program-Specific faculty of Kyoto University) who will lead the projects to the accomplishment. The principle investigators are desired to form their own research teams with researchers/research assistants who will support the projects, and to start up and drive forward the projects. Please visit the following CiRA webpage for detailed information on the job.

At first, research will be conducted in areas relating to heart failure, diabetes mellitus, neuro-psychiatric disorders cancer and intractable muscle diseases, but as the project progresses, we expect new areas to be added. When the project is progressing at full speed, we plan to work on approximately 10 projects simultaneously.

Event Information

Event report

2017.10.11~ 2017.10.13 T-CiRA research activity will be presented in BioJapan 2017.

T-CiRA research activity will be presented at the booth of Takeda Pharmaceutical Company Ltd. in BioJapan 2017 to be held at Pacifico Yokohama from 11th – 13th October 2017. Please visit our booth and learn more about T-CiRA.

Latest News

  • October 06, 2017
    "T-CiRA brochure" has been updated.
  • June 16, 2017
    "Project details" have been updated.
  • November 24, 2016
    "T-CiRA Brochure" has been updated.
  • November 11, 2016
    "Project Details" have been updated.
  • July 7, 2016
    "Recruiting Advertising" has been updated.
  • May 12, 2016
    Project Details has been updated.
  • March 16, 2016
    "Career Opportunities" has been updated.
  • December 15, 2015
    The special site for T-CiRA has been published.

For inquiries regarding T-CiRA

Takeda Pharmaceutical
Company  Limited Shonan Research Center

  • Phone: +81(0)466-32-2111
  • Fax: +81(0)466-29-4405

Email: T_CiRA@takeda.co.jp